The number of job openings fell to 8.8 million at the end of July, down from the prior month’s revised 9.1 million in a sign that the economy is downshifting, the Labor Department reported on Tuesday.
The drop brings the number about 2.5 million below the 11.4 million available jobs of a year ago.
Openings fell in professional and business services, down 198,000; health care and social assistance, off by 130,000; and state and local government, including education, where the combined losses totaled 129,000. There was a strong increase in information industry jobs, up by 101,000; and in transportation, warehousing and utilities, where openings increased by 75,000.
“Now it is taking a bit longer for jobseekers to find a job,” said Julia Pollak, chief economist for ZipRecruiter. “There’s meaningful slack in the job market, but it is still a historically tight job market. Overall, I still see the U.S. labor market as understaffed.”
The government will report the monthly jobs number for August on Friday with expectations for a gain of about 168,000 jobs.
“Investors should expect a softening labor report this Friday, further cementing the thesis that the Fed is getting close to finishing its tightening cycle,” said Jeffrey Roach, chief economist at LPL Financial.
Meanwhile, the Conference Board’s consumer confidence index for August found a pullback as Americans grew more concerned about rising prices of gasoline and groceries.
The present situation index – a reading of how consumers assess the current economy – fell to 144.8 from 153.0 in July. The expectations index, a forward-looking measure, declined to 80.2 from July’s bump to 88.
“Consumer confidence fell in August 2023, erasing back-to-back increases in June and July,” saidDana Peterson, chief economist at the business organization. “August’s disappointing headline number reflected dips in both the current conditions and expectations indexes. Write-in responses showed that consumers were once again preoccupied with rising prices in general, and for groceries and gasoline in particular.”
“The pullback in consumer confidence was evident across all age groups – and most notable among consumers with household incomes of $100,000 or more, as well as those earning less than $50,000,” Peterson added. “Confidence held relatively steady for consumers with incomes between $50,000 and $99,999.”
Consumers expected higher interest rates to come, while also lowering their assessment of the probability of a recession.
Also Tuesday, home prices rose 0.9% in June, according to the S&P CoreLogic Case-Shiller index. Prices were unchanged on a year-over-year basis.
"U.S. home prices continued to increase in June 2023," said Craig J. Lazzara, Managing Director at S&P DJI. "Our National Composite rose by 0.9% in June, and it now stands only -0.02% below its all time peak from exactly one year ago. Our 10- and 20-City Composites likewise each gained 0.9% in June 2023, and stand -0.5% and -1.2%, respectively, below their June 2022 peaks.”
"As we've noted previously, the recovery in home prices is broadly based,” Lazzara added. “Prices rose in all 20 cities in June, both before and after seasonal adjustment. Over the last 12 months, 10 cities show positive returns. Otherwise said, half the cities in our sample now sit at all-time high prices.
“Today’s market offers buyers the frustrating combination of low inventory and high home prices,” said Realtor.com economic data analyst Hannah Jones. “Many existing homeowners remain on the sidelines of the market, content to stay put as mortgage rates reach 20-year highs.”
“As a result, home shoppers are seeing fewer existing homes for sale and facing more competition for the homes available,” Jones added. “Builders have started to pick up construction activity to fill this gap, but remain cautious as affordability challenges continue to stifle buyer demand.”
。 由麦凯尔维工程学院机械工程和材料科学的Lilyan & E. Lisle Hughes教授Srikanth Singamaneni和Singamaneni实验室的前博士后Anushree Seth领导的研究人员开发了FluoroDOT测定法。该研究最近发表在《细胞报告方法》上。
B | 这种高度敏感的检测方法能够在大约30分钟内看到并测量单个细胞分泌的蛋白质。树突状细胞在不同时间点分泌蛋白1（TNFa，红色显示）和蛋白2（IL-6，黄色显示）的FluoroDOT检测图像（从左到右。未受刺激、受刺激30分钟、1小时、2小时和3小时）。细胞的细胞核以蓝色显示。白色箭头突出显示了只分泌一种蛋白质或两种蛋白质的不同数量和不同时间点的细胞。
C | 图像: Srikanth Singamaneni/华盛顿大学与来自其他大学和华盛顿大学医学院的科学家一起发现FluoroDOT检测法用途广泛，价格低廉，可适应任何实验室环境，并且有可能比目前常用的检测法更全面地了解这些蛋白质。生物医学研究人员通过分泌蛋白来了解细胞间通讯、细胞信号传导、激活和炎症等方面的信息，但目前的方法在敏感性方面受到限制，而且可能需要24小时的繁琐处理流程。质子-荧光是Singamaneni实验室创造的一种质子增强的纳米标签，比传统的荧光标签亮16000倍，信噪比超过30倍，这是FluoroDOT检测法与其他检测法的区别所在。Singamaneni说："质子-荧光剂是由金属纳米粒子组成的，它作为天线拉入光线并增强分子荧光团的荧光发射，从而使它成为一种超亮的纳米粒子。
D | "这种质子-荧光的超亮发射使用户能够看到极少量的分泌蛋白，这是他们在现有测定法中无法做到的，加上利用定制的算法，用每个簇或斑点的颗粒数量或点状图案，实现以数字方式测量高分辨率信号。
E | 此外，它不需要特殊设备。Singamaneni和他的合作者于2020年在《自然-生物医学工程》杂志上首次发表了他们的等离子体氟化物工作。
F | 这项正在申请专利的质子荧光技术由圣路易斯华盛顿大学技术管理办公室授权给Auragent生物科学有限公司。"使用一个简单的荧光显微镜，我们能够同时对一个细胞以及它周围分泌的蛋白质的空间分布进行成像，"Seth说，他作为Singamaneni实验室的博士后学者从事这个项目，并作为Auragent生物科学公司的首席科学家（细胞应用）继续从事这项工作。
G | "我们看到不同细胞类型的有趣分泌模式。这种检测方法还能同时观察来自单个细胞的两种类型的蛋白质。
H | 当多个细胞受到相同的刺激时，我们可以将同时分泌两种蛋白质的细胞与只分泌一种蛋白质或根本不分泌的细胞区分开来。"为了验证这项技术，该团队使用了从人类和小鼠细胞中分泌的蛋白质，包括感染了结核分枝杆菌的免疫细胞。合作者和共同作者之一，医学博士Jennifer A. Philips，医学和分子微生物学系的Theodore和Bertha Bryan教授，以及医学院传染病科的共同主任，已经在她的实验室中使用了FluoroDOT测定。Philips举例说："当结核分枝杆菌感染免疫细胞时，这些细胞通过分泌重要的免疫蛋白（称为细胞因子）做出反应。但不是所有的细胞都以同样的方式对感染做出反应。
I | FluoroDOT测定使我们能够看到群体中的单个细胞如何对感染做出反应--看到哪些细胞正在分泌以及朝哪个方向分泌。这在旧技术中是不可能的。
J |
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